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To determine fluorescence intensity, the mean gray value of the NPC area adjacent to the accumulated circles (Ic) and the residual NPC area (Ir) was measured and normalized by the median intensity of Ir.
This award recognizes the success of the Duke University Panhellenic Association in upholding the values and ideals of a Panhellenic through the areas of recruitment, Panhellenic structure, communication with your NPC area advisor, judicial procedures, Panhellenic programming, academics and Panhellenic community impact and relations.
Possibly, Balkan NPC patients represent an intermediate population in terms of epidemiology, as Balkan Peninsula shares the Mediterranean Basin and neighbors to North Africa, which is a known endemic NPC area.
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This is even higher than its incidence in the high endemic NPC areas in China, where it is 0.1 % in children [ 12, 13].
Two studies conducted in NPC-endemic area by Hong et al. [ 13] and Lin et al. [ 14] reported that after neoadjuvant chemotherapy over 90% of NPC patients were able to complete definitive radiotherapy, which is considered the mainstay treatment in NPC.
The long-term follow-up result from the phase III study of Xu et al. [ 22] will provide more direct evidence and knowledge about the role of NACT for LA-NPC in NPC-endemic area.
We carefully used the most appropriate exclusion criteria for analysis and provided more robust and the first prospective evidence with dose response relation from the largest cohort in an NPC endemic area.
NACT showed promising result in terms of overall survival and treatment tolerability in the NPC-endemic area and this treatment strategy seems to be another reasonable option at least in the NPC-endemic area [ 13, 14, 20].
Our results suggest that eliminating or prohibiting incense burning and wood fire use at home is of meaningful public sanitation significance, especially in NPC endemic areas in China.
In studies carried out in NPC endemic areas, the titer of anti-EBV IgA targeting reactivation antigens (such as VCA) has been shown to correlate with an increased risk of progression to NPC [ 30– 33] and reviewed in [ 34].
Therefore, for patients with locally advanced NPC in NPC-endemic area, the best timing to incorporate chemotherapy with radiotherapy is still an unresolved issue [ 8].
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