Exact(6)
Pupillary reflex dilatation (PRD) following a noxious event is measured with video recording (AlgiScan, IDMed, Marseille, France).
The mechanism of nociception is complex involving the detection of a noxious event by nociceptors, and signal processing in the peripheral and central nervous system (CNS).
Tetanic stimulation (80 mA, 30 sec., 50Hz), the most common used noxious event in clinical studies, was compared to Bromm's pain model, a direct intracutaneous stimulation (80 mA, 30 sec., 2Hz) of Aδ- and C-fibres [1].
CRPS type I (RSD) is defined as a syndrome that usually starts after a noxious event, is not limited to the distribution of a single peripheral nerve, and is disproportionate to the inciting event [3].
Symptoms usually appear after an initiating noxious event such as trauma or surgery [ 2, 3].
Central sensitization occurs when a noxious event in peripheral bodily tissues triggers a long-lasting sensitization of recipient spinal neurons that can continue long after the initial peripheral injury or pathology has healed.
Similar(2)
When no noxious events are occurring, these nerve fibres are silent.
As stated above, pain is not the inevitable result of the firing of nonmyelinated fibres reporting noxious events.
Related(2)
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