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However, further reduction seems necessary to avoid noxious effects on ecosystems.
WC Co mixtures, widely used in industry, have been intensively investigated because of their noxious effects on human health when the powder is inhaled.
We designed an experimental study aimed at evaluating the induction of possible noxious effects on testicular morphology and functions in A/J mice exposed whole-body to CS during the first 70 days of life, from birth to early adulthood.
57 In fact, repeated gestations have been found to have potentially noxious effects on health, and several hypotheses, discussed in a previous paper, 14 have been advanced (detailed discussion appears in the Appendix).
In addition to PPARγ, in mouse models of cardiac hypertrophy and heart failure, the activation of PPARα has also been shown to cause noxious effects on the development of the ventricular function [ 17, 19].
The anti-amyloid effects of p65/RelA overexpression on neuronal survival could not be studied, as p65/RelA overexpression induced neuronal death two days after transfection (that is, before Aβ had noxious effects on cultured neurons).
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As their applications to science and technology expand, the need to understand the putative noxious effects of ENPs on humans and ecosystems is becoming increasingly important.
We recently demonstrated that the noxious effects of Aβ on cultured hippocampal neurons are in part provoked by the antagonism of nerve growth factor (NGF) signalling, which impairs the activation of nuclear factor κB (NF-κB) by impeding the tyrosine phosphorylation of I-κBα.
These ventilatory conditions resulted in complete diaphragmatic inactivity and prevented noxious effects of a hypercapnia on the muscular contractile properties [ 2, 3, 24, 25].
Warren's legislation is ambitious and far-reaching, drawing upon her focus as a senator ― and before that as a civil servant and law professor ― on documenting and lamenting the noxious effects of lobbyists and special interests on public policy.
Soon after being available on the market, the first generation emulsions, made from soybean oil, were thought to have a noxious effect on the immune system, especially when given in great amounts.
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