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While they may appear to be only a petty public nuisance, they are part of a more noxious development — the privatization of public spaces and, ultimately, of public life.
"People have been refused entry to a cultural event due to the judgement of a dog and then the police have doubled down on that by banning them for the entire Olympic Precinct for six months… It is a new, noxious development".
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The present paper is devoted to second- and higher-tier test methods for the characterization of behavioral changes produced in rodents by exposure to noxious agents during development.
Noxious fumes, spills and development have turned much of the area into a wasteland, causing severe deforestation as well as desperate poverty.
In addition to PPARγ, in mouse models of cardiac hypertrophy and heart failure, the activation of PPARα has also been shown to cause noxious effects on the development of the ventricular function [ 17, 19].
We have only considered here, short-lasting noxious stimuli; the evolution of such a freezing during the development of chronic pain needs to be investigated carefully.
The town, which was founded in 1628 and was originally called Indian Bridge, provoked considerable criticism from early visitors because of its location by a noxious swamp and its unplanned development.
Propofol treatment, by inhibiting the NF-κB signal transduction pathway, might block the production of noxious mediators involved in the development of halothane-induced injury.
Genetic engineering approaches revealed a critical role of NaV1.8 in mediating pathologic pain: Nav1.8 knockout mice exhibited pronounced analgesia to noxious mechanical stimuli and delayed development of inflammatory hyperalgesia while exhibiting generally normal behavior [ 16].
These peptidergic neurons rapidly release CGRP upon noxious stimulation [ 34] and during development of acute joint inflammation [ 1, 35].
In addition, tissue injury and inflammation often accompany rapid development of hypersensitivity to noxious and nonnoxious stimuli (hyperalgesia and allodynia, resp).
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