This novel method of turnover analysis does, however, have several limitations.
In the present study, locomotor activity in a novel environment and dopamine turnover was significantly decreased in orexin-deficient mice compared to WT mice, which suggests that psychostimulants may be useful for maintaining wakefulness in orexin deficiency.
This assay represents both a novel marker of ECM turnover and a potential new tool to elucidate biglycan role during the pathological processes associated with ECMR.
A spindly genealogical tree is indicative of population turnover, wherein novel antigenic phenotypes continually replace more primitive 'spent' phenotypes, purging their genealogical diversity.
In conclusion, this study offers novel insights into histone turnover by using techniques complementary to those already in standard use by the general chromatin biology community to examine the role of histone turnover in epigenetic regulation.
Strikingly, the distribution of inferred gene gain and loss events is consistent with recent studies suggesting that the rapid turnover of novel genetic material in individual prokaryotic genomes represents a taxonomically widespread phenomenon.
Concentrations of the CS846 epitope in synovial fluid, proposed to reflect the turnover of novel aggrecan molecules [ 27, 28], showed a strikingly similar time course to GAG levels following induction of inflammation.
To this end, we will illustrate how the outputs from zeta diversity analyses can provide valuable and novel insights about the species turnover and community assembly processes in an Afromontane forest.
Overall our results show that SLK is a novel regulator of focal adhesion turnover and cell migration.
These data demonstrate that acute modulation of HBP and protein O-GlcNAcylation in the heart stimulates fatty acid oxidation, possibly by increasing plasma membrane levels of FAT/CD36, raising the intriguing possibility that the HBP and O-GlcNAc turnover represent a novel, glucose dependent mechanism for regulating cardiac metabolism.
