Sentence examples for novel rationale from inspiring English sources

This study not only enhances our knowledge of the immunopathological mechanism of uveitis but also provides a novel rationale to target CXCR4 as an anti-inflammatory strategy to treat uveitis.

Using these data in a restrained ensemble docking protocol, we obtained a model for the ternary complex that reveals a novel rationale for the hierarchical assembly of the complex.

Envisaging a novel rationale for an effective therapy, the current review summarizes the main cellular and molecular mechanisms underlying cisplatin resistance and the impact of chemotherapy challenge in CSC selection and clinical outcome.

The study revealed that frequencies of CD11bCD14CD33CXCR4 MDSC migration closely correlates with PGE2 and CXCL12 levels in patient ascites, suggesting a central role for PGE2 in MDSC accumulation regulated by the CXCL12/CXCR4 pathway and providing a novel rationale to target PGE2 signaling in ovarian cancer treatment (Obermajer et al., 2011).

Our mouse model provides a novel rationale with TME-targeted strategy for the development of cell-based cancer immunotherapy.

This provides a novel rationale for assessing the potential of drugs targeting the proteasome for their anti-fibrotic properties.

"Icons, Placeholders and Leftovers: Midtown East Report" advances some novel rationales against landmark designation.

Detailed knowledge about such synergistic interactions driving cancer and rigorous evaluation of the therapeutic benefit in appropriate in vivo models is an important prerequisite for the development of novel rationale-based combination therapies simultaneously targeting such cooperative signals.

Given the evidence mentioned above, our findings indicated the direct beneficial effects of IFR radiation on blood flow recovery after tissue ischemia, and IFR radiation counteracts the detrimental effect of a diabetic environment on improvement of EPC functions, which may provide some novel rationales for its potential clinical impact on vascular protection.

Therefore, there may exist a novel molecular rationale for new platinum antitumor drugs development in the twenty-first century.

A mechanistic approach to the discovery of key pathogenic brain modifications causing seizure onset, recurrence and progression is instrumental for designing novel and rationale therapeutic interventions that could modify the disease course or prevent its development.