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Since then, community-driven, challenge-based benchmarking efforts have been recognized as effective tools that are capable of enabling the evaluation of novel or existing computational methods39.
While the general yield criterion is developed as an extension of a specific non-quadratic anisotropic yield criterion, the same model development methodology can be applied to other novel or existing yield criteria that are defined in the deviatoric stress space.
An alternative approach to targeted therapy is to use novel or existing agents to enhance the efficacy of conventional therapeutics.
It is possible that novel or existing anti-topoisomerase agents target topoisomerase IIIa, suggesting that this enzyme may have potential as a prognostic marker and chemotherapeutic target.
Recent advances in understanding the pathogenesis of LAM, including the identification of promising therapeutic targets, have paved the way for testing novel or existing drugs [ 6].
This introduction could also contribute to their substitution with novel or existing serotypes that are better adapted to the ecologic niche.
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Current rapid technological advances in whole genome DNA sequencing, based on novel or previously existing principles, are gradually replacing established Sanger method variants.
More recently, the ability to readily characterize complete helminth mtDNAs, by means of long PCR and a variety of sequencing techniques [ 24, 25], has prompted an assessment of entire genomes as a source for phylogenetic analysis [ 26- 29], and their comparison to reveal variation within and between genes in order to develop novel (or optimise existing) molecular markers [ 30, 31].
This raises the possibility that constituents of tobacco smoke may have antidepressant and/or anxiolytic properties, which could lead to the development of novel pharmacological treatments, or novel indications for existing treatments currently used for smoking cessation.
Extreme cases are those examples in Figure 2, in which the retrocopy did not contribute much novel or pre-existing sequence space, but contributed to the formation of potential genes out of unannotated intergenic regions or retroposons.
A set of conclusions that emphasize new theoretical, modeling, or experimental contributions; or novel applications of existing theories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com