We use several tools to generate novel lead structures, such as BROOD [1].
Thus, FCP5 may represent a novel lead for the design of new major groove-binding compounds.
The further optimisation of the novel lead compound CGH752 (Fig. 1) is described.
IIf showed great promise as a novel lead compound for further anticancer discovery.
Further SAR optimization led to the discovery of a novel lead compound.
Compound 17 is a novel lead with low picomolar potency on all three Pim kinase isoforms.
We here report the preliminary structure activity relationship (SAR) studies of this novel lead compound.
Using the fibrate derivative GW590735 [6] as query, we designed a novel lead structure by substitution of the acidic head group and hydrophobic tail.
Considering these above results, we speculated that introducing 1,3,4-thiadiazole fragment into myricetin might generate novel lead compounds with greater biological activities.
This study provides a series of novel lead compounds for the development of non-azole antifungal agents.
So these five compounds could be used as novel lead compounds for further design of HDACs inhibitors.
