Taken together, IBR2 represents the first small molecule that directly binds RAD51, disrupts RAD51 multimerization, inactivates RAD51 functions both in vitro and in vivo, which suggests a novel entry point for developing potential therapies in compliment to current treatments for cancer.
Mime-seq overcomes current challenges in cell-type-specific small-RNA profiling and provides novel entry points for understanding the function of miRNAs in spatially restricted physiological settings.
Conversely, harnessing this sympathetic plasticity to regenerate the intra-adipose arborizations afflicted in metabolic disorders might provide a novel entry point for therapeutic strategy to restore the local sympathetic efferent outputs, and as the result, the metabolic homeostasis of WAT.
Insights derived from shared genetic susceptibility between POI and either age at natural menopause (AANM) or early menopause (EM) represent another potential path identifying novel entry points for unraveling genetic mechanism involved in POI.
Through the identification of cell types that have previously been underappreciated to play a role in the pathophysiology of atherosclerosis, novel entry points for drug design can be created.
For the more-is-better file, the C7 brings a novel entry: a 7-speed Tremec manual transmission.
Although no new cases of injectional anthrax have been reported since a case was diagnosed in November 2010 in Maidstone, England, this outbreak may indicate an emerging infectious disease in drug addicts in Europe and that illicit drugs such as heroin are a novel point of entry for this pathogen into non anthrax-endemic regionon anthrax-endemic
Surprisingly, the entry for Novel brackets Ivanhoe and A Tale of Two Cities with Northwest Passage (1937) by Kenneth Roberts.
The Wikipedia entry for the novel cites several reviews that surmise Silk was based on Mr. Broyard, who, as Henry Louis Gates, Jr., has written, "was born black and became white, and his story is compounded of equal parts pragmatism and principle".
Michael Cunningham's novel has an epigraph from Virginia Woolf's diary entry for 30 August 1923, when she was at work on her fourth novel, Mrs Dalloway.
