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This raises the possibility that tPA is a novel client protein for extracellular hsp90α.
We report here a novel client protein, the SUMO2/3 protease SENP3, that is sophisticatedly regulated by CHIP and Hsp90.
In this study we present evidence that extracellular hsp90α, secreted via exosomes, activates a novel client protein and increases tumor cell motility.
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We employed a kinase-directed chemoproteomics approach [ 16] to assess the protein levels of kinases after Hsp90 inhibition by geldanamycin in frequently used cell lines of three different tumour origins and one primary cell line in order to identify novel clients of Hsp90 and define cancer-relevant differences between non-transformed cells and cancer cells.
Another novel, The Client (1993; film 1994), sacrificed roller-coaster suspense for humour and slapstick energy.
Or what about your burgeoning novel or client documents!
In agreement, we recently identified MIF as a novel stabilized client of the HSP90 chaperone.
Recently, we identified MIF as a highly stabilized novel HSP90 client in cancer cells.
The intricate relationship between Hsp90α and its novel kinase client PKCγ can be easily illustrated by an Aesop's fable, The Farmer and the Viper.
That was followed in 2008 by a final novel, The Clients of Miss May, set in Hong Kong as the Chinese took over.
This book can be read as a novel about a client attempting to eat his solicitor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com