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Genetically encoded unnatural amino acids offer great promise for constructing artificial enzymes with novel activities.
Improvisation occurs when the design and execution of novel activities converge.
Novel activities and experiences shape the brain's structure and organisation and, hence, our behaviour.
These searches have led to proteins with novel activities, diversified specificities and greater stabilities.
Directed evolution uses laboratory-based evolution to enhance the properties of biomolecules, primarily to generate proteins with optimized or novel activities.
Giudicelli, F., Gilardi-Hebenstreit, P., Mechta-Grigoriou, F., Poquet, C. & Charnay, P. Novel activities of Mafb underlie its dual role in hindbrain segmentation and regional specification.
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Any novel activity (trying a new sport, new food, visiting a new place) activates dopamine".
Here in we report a novel activity of rocaglates- a synergistic effect with low doses of IFNγ on activation of Irf1 mRNA expression in primary (non-transformed) macrophages.
The enzyme also ligated double-stranded (ds) DNA templates, a novel activity not previously reported.
This novel activity of BSA to catalyze Gewald reaction is of practical significance in expanding the application of biocatalysts.
Lohman, J. R., Bingman, C. A., Phillips, G. N. & Shen, B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold.
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