Sentence examples for notwithstanding the difficulty of from inspiring English sources

Notwithstanding the difficulty of defining its 'concentration' in serum73, as most of it is bound to macromolecules, it is known that in type 1 diabetes the serum load of endotoxin (LPS) is raised relative to that of controls86, and that this is associated with disease progression87.

Notwithstanding the difficulty of an organization to classify itself as an "affiliate entity" of LSC, Gozdor argued that there was no real prevention of speech when there were ample alternative means of relaying the message.

Notwithstanding the difficulty of assessing the generality of the results, due to the fragmentary knowledge about the complete set of cellular LMs, distinct evolutionary patterns were identified.

Notwithstanding the difficulty of obtaining primary effectors in large quantities from tumor infiltrating lymphocytes, the present study shows that anti-4-1BB has a much more substantial effect on enhancing granzyme B expression in reactivated memory T cells as compared to its minimal effect on primary effectors (Fig. 4F).

Notwithstanding the difficulty of changing eating habits, this study adds further support to the need for targeting in elaborating health and nutrition campaigns.

Luckily for Ireland, those two years, notwithstanding the difficulty of the agreement's actual implementation, strongly refute O'Brien's grim analysis.

Notwithstanding the difficulties of teasing apart population size and selection effects on rates of evolution (see above), this is most likely due to the relatively small number of mutational events that occur between closely related samples, making it difficult to achieve a statistically significant number of nucleotide mutations between sequences.

Thus, notwithstanding the difficulties of modeling H+/e− transfers and the need to invoke the phosphate buffer to balance the various reaction steps, the DFT calculations generally support two consecutive one-electron transfers (pathway in Scheme 3 a), generating the transient IrII complex and the experimentally-detected semiquinone.

Notwithstanding the difficulty in proving that these candidate regions in fact reflect the action of positive selection (Hernandez et al. 2011), they display an outlier pattern of diversity that is consistent with positive selection and are enriched in true positives.

His endorsement of "Stoic impassability" notwithstanding, Montaigne also admits the difficulty of preserving professional detachment against the force of private emotion: "Yet that does not mean that this stratagem of mine has relieved me of all difficulties or that I have not often found it very hard to master or bridle my emotions".

Notwithstanding the difficulties underlying the execution of this type of complex clinical trials, larger and methodologically more robust trials are very much needed to confirm the findings of the present review, and to further identify characteristics of successful programs.