Sentence examples for notional threshold from inspiring English sources
Indeed, many pathological mutations may only be conditionally pathogenic, exerting a detrimental effect only if and when the genetic and external environments interact to push the phenotype over some notional threshold into pathology.
However, it should be noted that, according to MutPred, both the novel missense polymorphism p.A21P and the previously identified missense polymorphism [p.T641A (T625A)] have probabilities of being deleterious that lie close to the notional threshold (0.62 and 0.58 respectively) suggesting that they could be of functional significance.
Uncertainty was greatest for FIT, but the outlying simulations remained well below the notional cost-effectiveness threshold.
However, even when these were varied, the ICER for FIT vs no screening remained very much below the notional cost-effectiveness threshold, and in some instances became cost saving (ICER<0).
All three scenarios appeared to have favourable cost-effectiveness profiles when compared marginally against no screening (i.e. the ICER was significantly lower than the notional cost-effectiveness threshold of €45 000 per QALY).
The results of the one-way sensitivity analyses for FSIG and gFOBT were similar to those for FIT (i.e., the same parameters had the greatest impact, and in all instances, the ICERs for screening vs no screening remained very much below the notional cost-effectiveness threshold (data not shown)).
"For those who question the level of the de minimis, we considered the threshold in the context of an overall $300 trillion notional swaps market," he said, noting that $8 billion was hardly significant amid this huge market.
The fame is similarly notional.
Health, Ira decided, was notional.
