Although the notion of hub, referring to nodes with many connections to others, in the exponential degree distribution is not as strong as in the power-law degree distribution, we can still identify nodes with relatively large degrees and strengths by examining the "tail" part of the distributions.
Second, we found that, for two networks – namely, FYI and HC, the hub notion as defined by this transition agrees well with the hub notion defined by the ability to split the hub set into date and party hubs based on their neighbor coexpression characteristics.
We also found no agreement between the connectivity based hub notion and the expression based one for the HCh and LC networks.
Following this notion, mutating a hub protein of an essential network is most likely to have negative fitness affects.
Then, using the notion that in-hub genes will be differentially expressed over several experimental conditions, we designed an algorithm, the HubDetector, enabling identification of in-hubs directly from gene expression data.
The reason, auto executives and real estate brokers say, has less to do with current economic conditions and more to do with New York City's identity as a global hub — the notion that if a company can make it here, it can make it anywhere.
Patel sees this as the beginning of an important construct, the notion of a content hub where you can see the entire transaction record associated with a piece of content.
Moreover, traditional approaches are limited by the notion of defining candidates hubs by either counting the number of edges assigned to a node or by estimating the total intensity of the connections without providing an indicator of statistical significance (P value) for each candidate hub.
In yeast, there were early notions that network hubs showed a tendency for accumulation of essential phenotypes [ 53], but this finding was blurred with emergence of larger data sets [ 54].
The development would also turn the Nassau Hub from a notion into a reality, creating a central axis for the Garden City government complex, Roosevelt Field, Eisenhower Park, Hofstra University, Mitchel Field, Nassau Community College, downtown Hempstead, EAB Plaza and the Nassau University Medical Center in East Meadow, whose 19-story building is now the tallest on Long Island.
