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In keeping with this notion, cells from raver1-null mice were indistinguishable from wild type cells and displayed normal growth, motility, and cytoskeletal architecture in culture.
Second, genetic tagging of myeloid cells with GFP confirms this notion; cells that have passed through the myeloid lineage are found integrated into the lymphatic vasculature surrounding tumors.
Consistent with this notion, cells remained attached to the plates and DNA synthesis (as measured by BrdU and PI incorporation) was reduced in NPM-ALK-expressing cells to a level comparable to that of H-Ras V12-expressing MEFs (Figure 2A).
In line with this notion, cells treated with a SMAC mimetic (resulting in the depletion of BIRC2 and BIRC3) or a chemical TAK1 inhibitor (NP-009245) reportedly respond to TNFR1 ligation by activating caspases in a RIPK1-dependent manner.
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In vitro data support such notion; cell lines with miR-21 overexpression increase cell proliferation, migration and invasion [ 26].
Consistent with this notion, cell lines mutant for the p65/RelA component of NF- κB are killed by TNF alone.
Consistent with this notion, cell autonomous expression of wild-type UNC-116 in unc-116 e2310) unc-116 e2310ed the dendritic distribution phenotype of KLP-16, indicating that UNC-116 functions in the DA9 neuron.
To test this notion, ctf7-203 smc3Q cells were crossed to ctf18 deletion cells and the resulting diploids sporulated.
As a general notion, HeLa cells are much more resistant than many cell lines.
Consistent with this notion, revertant cells showed a less differentiated morphology than prion-susceptible cells (Supplementary Fig S1).
It also further strengthens the notion that cells were generally competent to extend and cover other cells.
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