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Reactions to these notifications varied.
The percentage of CR-only notifications varied between registry zones (P<0.001), ranging from 2% in Mersey and the West Midlands to 22% in Wales.
In those age groups, percentages of varicella notifications varied between Regions but were >80% of the overall notified cases in all of them (data not shown).
Under feedback assumption (A), the percentage of CCLG-only notifications varied between diagnostic groups, ranging from 0% for hepatic cancer to 17% for retinoblastoma (P=0.036).
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The median time between the recommendation for protocol suspension and patient notification varied from 7 49 days with three of the four trials at 12 days or fewer.
Means of notification varied from calls, to letters, to no notice at all.
The case notification varied substantially in the control districts during the study period and more synchronized case management efforts are required.
CR-only notification varied between diagnostic groups (P<0.001), ranging from 0 3% for leukaemia, neuroblastoma, retinoblastoma and renal/hepatic cancers, to 14% for germ-cell/gonadal cancers, 39% for melanoma/carcinoma (i.e., malignant melanoma and non-skin carcinoma not included in other groups), and 78% for other/unspecified cancer (from only 23 registrations).
In one-way sensitivity analyses, none of the parameters had a substantial influence on the predicted number of TB notifications when varied within plausible ranges (data not shown).
In addition, notifications have varied markedly from year to year for reasons not yet explained.
The percentage of CCLG-only notifications also varied between zones (P<0.001), and was highest in Eastern (10%) or Thames (6 18%), depending on the feedback assumption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com