EDI among the notifications was defined as 14 days before the reported date of onset of PHI symptoms or the mean date between the last negative and first positive HIV-test.
Potential TB patients required notification were defined as those who have TB-related ICD-9 codes (010-018) in the NHI reimbursement database in 2005-2007, werewere not diagnosed with TB in previous year, and who have been prescribed with 2 or more types of anti-TB drugs.
As shown in Figure 1, the interval between timepoints onset (T0) and notification (T5) was defined as the period from onset of symptoms until notification (Po); the interval between timepoints diagnosis (T2) and notification (T5) was defined as the period from laboratory diagnosis until notification (Pd).
Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory.
Duration of investigation was defined as time from notification of the LACDPH to closure in the outbreak log.
Analyses were conducted overall, by professional category and the TB incidence of the HPU area in which respondents worked (low, medium and high incidence defined as an annual notification rate of <10/100,000 population, 10 to 19/100,000 and ≥20/100,000 respectively).
11 An incident cancer was defined as a cancer diagnosis notification C00-C966, exC44ding C44) after hospital admission for index burn injury.
The time to central appraisal (TC) was defined as the delay from symptom onset to the notification received at the central level (KCDC).
Cardiovascular death was defined as cause of death coded in the USRDS death notification form as myocardial infarction, atherosclerotic heart disease, cardiomyopathy, arrhythmia, valvular heart disease, cerebrovascular disease and mesenteric infarction.
Additionally, the time to registration (TR) was defined as the delay from symptom onset to the doctor's notification to the local PHC.
