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Telomeres and subtelomeric sequences are noticeably hard to assemble when using shotgun sequencing.
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When French dance music rose again in the mid 2000s, thanks to Justice et al, the sound was noticeably harder.
The Obama administration, which has taken a noticeably harder stance against Mr Karzai than the Bush White House, is said to prefer a second-round run-off between Mr Karzai and Dr Abdullah to at least maintain the appearance of probity.
A recent survey of economists by the University of Chicago showed that a narrow majority of respondents believe a rise in America's minimum wage to $9 per hour would make it "noticeably harder" for poor workers to find jobs.
"I think grinding it out when you don't quite have it and you post a pretty good score is a sign that there's no give-up," said Donald, whose attitude has become noticeably harder since working with the performance coach Dave Alred.
Whatever the true reason or reasons (and I've heard tell that the real problem was that Brookhiser is not a Catholic and isn't even noticeably religious), it was a hard blow, obviously.
The photograph is noticeably detached: distinguishable features are hard to make out, to the point that some appear to blend into the hill behind them, and people are not moving or shouting or laughing, they're simply waiting.
Federal law enforcement has been noticeably absent, even in areas hardest hit by the crisis, such as Las Vegas.
But in other ways, they are noticeably dissimilar – and that is far harder to explain.
by Charles McGrath As political conventions go, the Democrats' gathering in New York last week was noticeably lacking in spontaneity, not to mention hard news.
E-mail address GO SIGN UP Share Tweet by Charles McGrath As political conventions go, the Democrats' gathering in New York last week was noticeably lacking in spontaneity, not to mention hard news.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com