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Curcumin and DMC had similar effects on Bim and KDEL, slightly increasing the protein levels of Bim but not noticeably altering the expression of KDEL.
First, ATP can bind to a kinase domain without noticeably altering its inactive conformation, as judged by the unchanged position of the αC-helix in apo-CDK2 and in CDK2 ATP Mg complexes.
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At some point in the only slightly distant future, this deplorable imbalance will be, quite noticeably, altered.
While such approaches have been rigorously verified in the dilute limit (where particles do not noticeably alter their carrier flow), much less verification has been attempted for cases where the coupling between the two phases leads to non-negligible modifications in the local fluid velocity.
Such behavior is noticeably altered for hMSCs cultured on 40-μm Si/20-μm PS micropatterns.
Comparing the columns of Table 2, we see that these alternative specifications do not noticeably alter the results.
The cerebellar kinetics of each radioligand was not noticeably altered by these pretreatments (Fig. 4a f), indicating the availability of the cerebellum as a reference region for quantitative analyses in rats.
HCVpp entry efficiency, as indicated by the luciferase activity in HCVpp-transduced Huh7.5.1 cells, was not noticeably altered by RBM24 silencing or overexpression (Fig. 2A), suggesting the lack of influence of RBM24 on HCV entry.
The morphology of tendon microarchitecture is noticeably altered following intratendinous injection with a fluid bolus, whereas needle fenestration did not appear to have a significant effect on visualized tendon morphology.
Think of this: Just your breath on a glass of water has enough CO2 to noticeably alter the pH in a glass of water.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com