At the highest tested concentrations, there was a noticeable down-turn in responses, giving rise to an inverted U-shape.
In a recent study Liovic et al. [ 33] showed that mutations in keratin genes caused noticeable down-regulation in many of the keratin-interacting components.
Interestingly, in our in vitro study recombinant IL-22 resulted in a noticeable down-regulation of Reg2 and Reg1 expression in the islets from 6-week-old NOD mice when incubated with high concentrations (50 ng/mL) of IL-22.
In tibiae from WT mice, the most noticeable down-regulation in Sost expression was observed at the 12-h time point after loading (− 2.0-fold) (Fig. 3A, Table S6).
The influence of maldistribution of the phases is noticeable for down-flow condition.
Most telling has been the noticeable slowing down in performances in the crucial mountain stages.
But there was a noticeable slow down in both large corporate clients and boss-driven clients.
Compatibility problems exist with older hardware, and plugging in too many U.S.B. devices at the same time can cause a noticeable slow down.
Whereas in the so-called real world we rush and strut, there is a noticeable slowing down in our walking speed at the festival.
The catalyst is reusable without noticeable turn down in catalytic performance up to five cycles.
