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In patients with TB and HIV, cutaneous anergy is thought to be an all or nothing effect and so there may be little gain in terms of reducing false-negative TST results by lowering the cut-off from 10 mm to 5 mm [20].
54 During the periimplantation and immediate post-implantation periods, radiation has an all or nothing effect, resulting in either embryonic death or further normal development.
The something from nothing effect has demonstrated that mixtures of environmental oestrogens at their no-observed-effect concentrations can give measurable oestrogenic responses in vitro [ 20], and we have found the same when mixing five different parabens.
Because of the apparently greater sensitivity of NR as an anti-androgenic end point, the something from nothing effect could not be evaluated with a combination of 24.5 mg/kg/day vinclozolin, 0.77 mg/kg/day flutamide and 14.1 mg/kg/day procymidone, because the individual doses induced NR that clearly reached statistical significance.
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"We felt good about bringing Chris in that game because nothing effects him.
He was subsequently diagnosed with a prolapsed disc, and despite multiple alternative therapies, nothing effected a permanent solution to the injury; he was subsequently in severe pain while shooting several of his films.
These in vivo results were consistent with the "something from nothing" effects reported by Silva et al. (2002), which were produced using in vitro techniques.
"Something from nothing" effects should occur even when individual toxicants are present at doses below effect thresholds, provided sufficiently large numbers of components sum up to a suitably high total-effect dose.
It is important to note that ubiquitination of plasma membrane receptors does not lead to an all-or-nothing effect, but rather modulates the intensity and duration of signalling events, serving a 'fine-tuning' role.
As all inhibitors, with the exception of LK1, were found to be totally inhibitory at 100µM we started testing six prodrug derivatives of LK1 at 50µM to detect a first "all-or-nothing" effect.
A complicating factor in this study was the difficulty in identifying farms where both positive and negative pigs of the target age were present, since an 'all-or-nothing' effect was apparent on many farms.
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