Sentence examples for noteworthy affinity from inspiring English sources

Indeed, in addition to a noteworthy affinity (Ki = 4.7 nM) for the α3β4 subtype and to an excellent α3β4 vs α4β2 subtype selectivity (806-fold), compound 12 selectively activated the α3β4 nAChR (EC50 = 7.4 μM) while eliciting a negligible response at the α7 subtype and no effect at the α4β2 subtype.

It is noteworthy that the affinity of the PLAD PLAD interaction is rather low and almost in the mM range.

However, it is noteworthy that the affinity of Insecta and Collembola was resolved under the model of CAT + mtArt, while the grouping of Collembola with Diplura was recovered under the model of mtArt using only moderate-rate sites.

These non-specific binding interactions are captured by the reaction 4. It is noteworthy that the affinity of the repressor for tetO2 is about 5 times higher than for tetO1 [ 34].

It is noteworthy that the affinity of PARs for Ctcf is strikingly higher than that of H2B taken as positive control [ 35] and that the interaction persists even in the presence of competitor DNA [PARs:DNA ratio of 1 25 (w/w)]; the latter was used to rule out non-specific interactions due to the highly negatively charged nature of PARs.

Noteworthy, the reported binding affinity of CXCL12 for CXCR7 (Kd ∼ 0.2 0.4 nM) is considerably higher than for CXCR4 (Kd ∼ 2 4 nM) [5], [7], [32].

It is noteworthy that the low affinity of SmAQP for lactate (Km = 41 mM) is similar to that of the rat lactate transporter MCT4, expressed in Xenopus oocytes, whose Km = 34 mM [32].

In this regard, it is noteworthy that the low-affinity transporters contain an SPX domain in their N-terminus, which is also found in other proteins with important regulatory roles in Pi homeostasis in yeast, including Pho81 and the proteins of the vacuolar transporter chaperone (VTC) complex involved in vacuolar polyphosphate homeostasis (Secco et al., 2012).

Finally, it is noteworthy that DHE also displays moderate affinity for other receptors, including the 5-ht1E (pK i : 6.2) subtype (Table 1).

It is also noteworthy that DES has a higher affinity for the two receptors (0.13 and 0.15 nM for ERα and ERβ respectively, similar to estradiol; [26] compared to the specific agonists for their respective receptors (PPT: Relative binding affinity for ERα where E2 is 100%: 20 50%; DPN: Relative binding affinity for ERβ where E2 is 100%: 5 20%; [41], [42], [109].

It is noteworthy that the disparity between the affinities of IP3 and AdA and their dephospho analogues was exaggerated in TEM.