Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system.
The beginning of the 1950 Atlantic hurricane season was considered "remarkably quiet" by the U.S. Weather Bureau, with no noteworthy activity until early August.
However, nanocurcumin demonstrated more noteworthy activity against Gram-positive bacteria rather than Gram-negatives [ 95].
Terminalia sericea was the only plant species to show broad-spectrum activity for the aqueous extracts having noteworthy activity against five of the seven pathogens studied (Table 1).
The organic extracts showing the broadest spectrum of activity were S. birrea and Garcinia livingstonei (noteworthy activity against all pathogens and mean broad-spectrum MIC value of 0.45 mg/mL), followed by T. sericea (noteworthy activity against six of the seven pathogens tested with a mean broad-spectrum MIC value of 0.52 mg/mL).
41, 42 Results from the Pediatric Preclinical Testing Program have indicated that sirolimus has broad antitumor activity against in vivo panels of childhood tumors, with noteworthy activity in select sarcoma and acute lymphoblastic leukemia xenografts.
The organic extracts of Elephantorrhiza elephantina, Ekebergia capensis, Eucalyptus camaldulensis, and Harpephyllum caffrum displayed noteworthy activity against P. acnes with MIC values between 0.05 and 1.00 mg/mL [ 65].
If we consider the alternative criteria described by Fabry et al. [ 30], where extracts having MIC values less than 8000 μg/mL have noteworthy antimicrobial activity, the overall activity recorded with the leaves and fruit extracts of B. acuta, P. fulva and N. laevis leaves extracts can also be considered promising.
If we considered the alternative criteria described by Fabry et al. [ 48], where extracts having MIC values below 8000 μg/mL have noteworthy antimicrobial activity, the overall activity recorded with most of the studied extracts can be considered important, notably the extracts from P. fernandopoina, B. obscura, V. soyauxii and P. staudtii leave s.
The preliminary bioassays indicated that most of the title compounds exhibited noteworthy cytotoxic activities.
