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Again, no difference in lymphatic vessel width was noted (Supplementary Fig S4Aiii).
Mutations and integrated transgenes used are described elsewhere (Riddle et al., 1997), except when otherwise noted (supplementary material Table S1).
No changes in bilirubin, heart rate, or in the proportions of patients experiencing orthostatic hypotension were noted (Supplementary Table A5).
As expected for independent prognostic markers, most associations failed significance, even though some dependencies became apparent, particularly with Gleason score and serum PSA, but high correlation coefficients were not noted (Supplementary Table S3).
A χ statistic with one degree of freedom was calculated for the 16 possible combinations of 3′ 5′ preference at the ligation junction and where P<0.0001, this was noted (Supplementary Table S1 at http://www.biochemsoctrans.org/bst/041/bst0411189add.htm).htm
Any gene needing no change to its current annotations was scored as 'no change', while those needing additional information or corrections to the existing set of annotations were scored 'updatable' and the type of update made based on each flagged annotation was noted (Supplementary Tables S1 and S2).
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Note: Supplementary videos are available at www.ajtmh.org.org
From BLAST results (tBLASTn, E < 10−), 432/458 KOG groups (94.3%) were shown to be present as noted in supplementary file S1, Supplementary Material online, with 349/458 (76.2%) supported by all six species used by CEGMA.
This has been noted in supplementary file S3, table S1, Supplementary Material online.
Since the publication of this article, it has been noted that Supplementary Figure 3 was identical to Supplementary Figure 4.
In addition to the ancillary analyses as outlined, the following patient related protocol deviations were noted (see supplementary files Protocol S1 and S2 as well as Amendment S1 for details).
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