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In addition to the questions regarding efficacy, there may also be concern for safety, as some studies have noted formation of tumors in MSC cultures from mice, and evidence of cell death due to inflammation and reactive oxygen species[57].
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When CD14+ monocytes were co-cultured with either Ewing's sarcoma-derived fibroblasts or bone stromal cells, in the presence of M-CSF, evidence of osteoclast formation was noted with formation of TRAP+ and VNR+ MNCs.
He prepared hydrochloric acid from common salt and sulfuric acid and pointed out the virtues of the residue, sodium sulfate sal mirabile, or Glauber's salt; he also noted the formation of nitric acid from potassium nitrate and sulfuric acid.
We noted the formation of calcifications arranged mostly along the anterior capsule and collateral ligament complexes in follow-up X-ray examinations (Fig. 6).
We noted that formation of a single giant phagosome often preceded Outcome I type cell division.
One stage comes at D13.5, the point at which we noted eye formation was initiated.
The latter study noted the formation of two extracellular radiolabelled metabolites suggested to be the 2- and 4-hydroxylamines.
It must be noted that formation of hMSC aggregates or clusters, which also happened in these droplets, could also be valuable for differentiation purposes.
In 9 infected animals (clinical and preclinical), we noted nidus formation in the lumina of the bladder with a few neutrophilic granulocytes.
We also noted the formation of some strings with a comparable length to those formed under control conditions (data not shown).
For example, two studies have noted the formation of hydroxylated, oxygenated, and methoxy derivatives during microbial and fungal degradation of PAHs [ Wunder et al., 1997; Andersson et al., 2003].
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