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Should the sponsor decide not to fully implement the advice of the DSMB, the sponsor will send the advice to the reviewing METC, including a note to substantiate why (part of) the advice of the DSMB will not be followed.
Should the principle investigators decide not to fully implement the DSMB recommendations, the principle investigators will send the recommendation to the accredited medical ethics committee, including a note to substantiate why (part of) this recommendation will not be followed.
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In order to substantiate the noted and reported act of SMFP on DNA molecule that would subsequently affect DNA analysis when proving criminality of event during forensic investigation.
Let me just note that a lot of work is needed to substantiate this sort of challenge.
Representative John Conyers of Michigan asked Lynch to address the topic, noting that he knew of "no real evidence to substantiate this claim".
The Foreign Office declined the request, noting: "The South Africans were able to produce no evidence to substantiate their claims".
We speculate that this difference reflects how asymmetrical use of the upper limbs is more common than for the lower limbs, but further research is necessary to substantiate this hypothesized rationale for the differences noted.
It should be noted however that the actual behavior of populations in developed countries appesar to substantiate our observations.
Note, however, that PRO instruments that measure a simple concept may not be adequate to substantiate a more complex claim.
The observations and notes from the support group meetings and the interviews with the traditional healers were used to substantiate the findings from the interviews with the counsellors.
It also should be noted that our study was limited to a single measurement and further work with serial measurements is needed to substantiate the variability of the marker for risk stratification.
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CEO of Professional Science Editing for Scientists @ prosciediting.com