We do not feel this hindered our ability to test the ReproQ psychometric properties, but have noted difficulties with these items for future surveys.
However, we noted difficulties with the concomitant implementation of new IT technology for recording and reporting test results, which negatively impacted the time necessary to get lab diagnosis to physicians.
Before surgery, trismus, megaloglossia, and the disturbance of cervical vertebral excursion were noted, suggesting difficulties with ventilation/intubation.
Patients' notes documented difficulties with inter-professional working in terms of communication and in deciding which service was responsible for care when patients were moved between boroughs.
A slight elevation was noted for difficulties with disorders of initiating and maintaining sleep (65T) and total sleep problems (60T), but both placed in "at-risk" range and did not exceed the recommended clinical cutoff (70T) for the subscale.
Second, it is important to note the difficulty with data such as ours to reliably quantify direct and indirect effects due to unmeasured confounding [ 41, 42].
In addition to the potential psychological distress involved with volunteering, participants noted difficulties related to logistics surrounding HST volunteering.
Other authors have discussed whether PFS data is acceptable to FDA and EMA (19) and have noted difficulties in reconciling positive PFS results with the lack of clear benefit in OS outcomes (20).
He noted difficulties in the recording process, including arguments with West regarding their direction.
In addition, exome capture suffers from highly variable coverage, cannot be optimized for specific genes of interest, does not include introns, which are likely to be a rich source of disease-associated variation and as noted above present difficulties with analysis of the mitochondrial genome (Picardi and Pesole, 2012; Guo et al., 2013).
