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In addition, blockade of Notch results in altered lymphocyte development including decreased number of mature B-cells [40].
These latter observations account for the spatial profiles of DeltaC in figure 12. Spatial profiles of Notch (results not shown) reveal that its distribution is changed little by signalling.
During pancreatic and motor neuron development, activation of Notch results in increased expression of Hes genes that repress expression of the proendocrine gene Ngn3 and the pro-neural gene Ngn2, respectively, thus maintaining cells as undifferentiated progenitor cells [12], [13].
DOI: http://dx.doi.org/10.7554/eLife.02950.013 Removing one copy of Notch results in wing vein thickening and the classic 'notched' wing phenotypes (Mohr, 1919).
Such regulatory mechanism would explain, for example, that loss of Notch results in stem-like/round cells (Micchelli & Perrimon, 2006; Ohlstein & Spradling, 2007).
It is clear therefore that activation of Notch results in complex effects on tissue growth, as epitomized by its diverse effects in wing imaginal discs, but how these disparate outcomes are coordinated is unclear.
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As the task difficulty increased with decreasing notch, resulting in poorer performance, we could tentatively say that task difficulty (or attentional load) did increase the proportional attentional effect or sensory gain, but only to a certain extent, which could even be related to the physiological limits of the human auditory system (the critical band).
Use the angle grinder to cut off the notch, resulting in a continuous straight edge for the lower blade chamber wall.
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