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Notably, normal and tumor decellularized matrices distinctly promoted macrophage polarization, with macrophages in tumor matrices differentiating towards an anti-inflammatory M2-like phenotype (higher IL-10, TGF-β and CCL18 and lower CCR7 and TNF expression).
Notably normal human skin does not display overt inflammation, suggesting that SDF-1 may function as an important mitogen in physiological conditions rather than as a chemokine, a well-known major function of SDF-1 which activates leukocytes and is often induced by proinflammatory stimuli.
Notably, normal SVZ-derived cells underwent mTOR but not analogous Akt, Stat3 and p70S6K activation following high oxygen acute exposure, suggesting differences in oxygen sensitivity between tumour and normal cells.
Notably, normal physiological O2 concentrations vary greatly from normal oxygen tension in the air depending on the type of tissue.
Notably, normal cells typically respond in a facile manner to "correct' DNA damage responses once the test agent has been removed.
Notably, normal ductal epithelium in both age-matched controls and wildtype animals did not stain positively for PyV mT or Cre recombinase.
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Samples in major cluster 1 appear to be negative for the CIMP phenotype and were designated CIMP ve with sub-cluster 1a appearing to be notably normal-like, including all the control normal samples, whilst sub-cluster 1b has low level methylation.
One of the first prominent advocates in the early 1980s for government action against H.I.V. and AIDS, Mr. Kramer went on to help found the Gay Men's Health Crisis and Act Up and to write acclaimed plays about gay men and AIDS, most notably "The Normal Heart," which won the Tony Award for best play revival on Broadway in 2011.
Notably, in normal SVZ cells SDH activation was not changed following BMP2 treatment (Figure S2A), this indicating differences in metabolic response to BMP2 treatment between normal and tumor cells.
3-M syndrome is an autosomal recessive disorder characterized by severe pre- and postnatal growth retardation and a characteristic facial appearance, but notably with normal intellect.
Notably, both normal C cells and MTC tumor cells are able to form follicles in vivo (Harach and Williams, 1983), suggesting common traits of epithelial organization.
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notably ordinary
distinctly normal
especially normal
specifically normal
namely normal
mainly normal
permits normal
fronts normal
notably harsh
notably cautious
notably different
notably unpresidential
notably strange
notably acidic
notably good
notably unlusty
notably friendly
notably chatty
notably moderate
notably poor
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com