These concerns arose out of the growing body of evidence of the negative impacts of detention on physical and mental health, notably long-term detention and detention of vulnerable individuals such as children and survivors of torture and trauma.
Notably, long-term remission was achieved in four of eight mice.
Notably, long-term survivors included those without an objective response to ipilimumab.
Thus, we have previously proposed a useful, ethanol-preferring rat model for studying OC, and, notably, long-term mel therapy significantly reduced OC masses and the incidence of adenocarcinomas [ 12].
Notably, long-term BP therapy is associated with ONJ, although its estimated frequency in patients taking oral BPs for osteoporosis is less than 1 case per 100,000 person-years of exposure [ 28].
Substantial effects of radiotherapy plus ZD1839 in vivo, notably long-term tumour regression, have been confirmed in the handful of additional studies reported for a range of cancer cell xenografts, including mammary MDA-MB-468 [ 17, 19].
Notably, long-term shRNA-mediated knockdown of AXL did not significantly reduce cell proliferation in vitro, which may be due to activation of other pro-tumorigenic RTKs upstream of PI3K or MAPK signaling.
Most notably, long-term exposure to natalizumab increases the risk of progressive multifocal leukoencephalopathy (PML), an opportunistic infection caused by the John Cunningham virus (JCV), which can reactivate in patients who are immunocompromised [ 74].
Notably, long-term tumor-free survival (exceeding 133 days) and complete tumor regression were observed in pancreatic xenografts (MIA PaCa-2), head and neck xenografts (SR475), and prostate xenografts (DU145, a cell line that represents a hormone-resistant entity established from a prostate cancer brain metastasis).
But it takes heroic optimism to believe that this will give the NHS the wriggle room to reform the way care is delivered to make the current range of NHS services sustainable for the long term, notably by moving much more care out of hospital.
