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Notably, effects of metformin in improving glucose homoeostasis in high-fat mice are abolished through a cocktail of broad-spectrum antibiotics [ 149].
Higher levels of active MMP-9 were shown to compromise BBB integrity in Apoe −/− and APOE4 mice; notably, effects on the vasculature preceded neurodegeneration.
Notably, effects for sex and age subgroups are all larger than the overall result, and these results should be interpreted with caution.
Notably, effects of sex hormones in EAE have also previously been shown to be dependent on genetic background [ 72] and some autosomal gene linkages to susceptibility to MS have been identified in one gender but not the other [ 73].
Rather than a resistance factor to Aβ, a third hypothesis postulates that factors other than Aβ mediate cognitive deficits in AD, most notably effects of cerebrovascular disease and neurofibrillary tau pathology.
Notably, effects on lipid transport may have a particular impact on synaptogenesis and neurodevelopment, as discussed in a later section of this review, as well as the ability to repair membrane damage.
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When play resumes, Pironkova's movement doesn't appear to be notably effected, but her timing is horribly off and she loses the game to love.
Notably, effect sizes are largest for the clinically critical stage IB and II patients.
The inhibitory effect of bexarotene was not due to cytotoxicity, as neither concentration produced notably effect on cell viability (data not shown).
Notably, these effects were evident 1 month after the intervention, clearly indicating the effect was durable.
Notably, no effects of treatment on sweat chloride, a surrogate marker of CFTR function in vivo, have been reported [12].
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