In the leukemia trial [ 9], multiple amendments, most notably amending the primary endpoint, were made subsequent to interim analysis with knowledge of treatment-arm specific rates in an apparent attempt to increase the number of events accrued and achieve a successful trial, but a substantial bias was introduced.
Important achievements in legislation - notably the 2008 amended Child Law, the Criminalisation of FGM/C and the Law to Combat Human Trafficking of 2010 - were not accompanied by the necessary government resources to implement the new legislative provisions.
Finland adopted a republican constitution in 1919; it has been amended several times, notably in the mid-1990s.
In making its decisions, the center uses various sources of information such as patient records, radiographs, statements by external medical experts, and most notably the Patient Injury Act of 1987, amended in 1999.
Notably, this recombinant EMCV behaves much like the EMCVΔL virus (amended Figure 6 of the paper), which indicates that the specific L region sequence of EMCV and not just the location within the genome is important for IFN production.
Notably, the $1.1 billion option on the building has now also been amended.
The commission's guidelines have been amended several times since they were first implemented, most notably in 2008, when crack cocaine was reduced by two "offense levels" on the table.
Full coordination is precluded for several reasons, most notably the rapid pace of change and the addition of new or amended systems at a faster rate than the coordination process can develop.
(In the amended version of "Touch of Evil" that was released in 1998, these effects are more apparent, notably in the ticking-bomb tracking shot that opens the film).
