However, there was notable variability in symptomatic responses to going outside, even although the group was selected for self-reporting difficulties in such situations.
It's notable that the symptomatic participants also reported lower scores for ocular pain and mental health, even though they didn't have any definite signs of DES.
It is notable that all of the symptomatic participants in Acosta-Baena and colleagues' study had objective cognitive deficits by the time they manifested symptoms.
Notable differences between our samples include symptomatic status, as Alexander and colleagues included only clinically remitted patients, whereas 65% of the patients in the present study were in a depressive episode at the time of investigation.
Most notable were two study participants (patients 21 and 22) who had symptomatic progressive disease prior to study entry.
It is therefore notable that vertebral fractures are often asymptomatic or mild-to-moderately symptomatic [ 2, 21, 22]; thus, under-diagnosis [ 9, 22, 23] and under-treatment [ 24] are major problems.
It is notable that English proficiency did not predict membership in any of the symptomatic classes, despite research suggesting that proficiency in the language of the host country is associated with poorer mental health outcomes [ 40, 41].
Comparable number of patients in HORIZON-PFT 29 and in HORIZON-RFT 30 had notable declines of serum calcium levels (to <7.5 mg/dL) after administration of ZOL; but no symptomatic cases of hypocalcemia were observed.
The rate of adverse reactions to hyperbaric therapy in this study was notable; one patient died (in the HBOT group, possibly related to treatment), 5% had significant barotrauma, and 6% had symptomatic hypoglycemia (one of whom was hospitalized), a known potential risk of HBOT.
In the present study it is notable that the effect on glycemic control was not associated with systematic change in insulin dosage or with an increase in symptomatic hypoglycaemia.
