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A notable role for an immunoregulatory glycan binding protein, galectin-1 in inducing tolerogenic DCs and supporting their capacity to generate decidual Tr1 cells is shown by loss of allogeneic pregnancies in mice deficient in galectin-1 (Blois et al., 2007a).
Given that certain reconstructions of LUCA posit a notable role for RNA-based genetic material [ 23], it is possible that this ancestral enzyme might have had a prominent role in LUCA as an enzyme that repaired RNA through its polymerase or nucleotidyltransferase activity.
Furthermore, B-cell activation of the TNF family (for example, by B-cell-activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), and a proliferation-inducing ligand (APRIL)) has further substantiated the concept of a notable role for B-cell cytokines in the pathogenesis of SS [ 17].
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Other notable roles for Finkel, who won the Emmy in 1994 for "Picket Fences," included eccentric teacher Harvey Lipschultz on "Boston Public" and attorney Murray Chotiner in the 1995 bio-drama "Nixon".
One of the most notable roles for siRNAs is within the RNA interference (RNAi) pathway, where the endogenous siRNAs help to regulate gene expression through Dicer-mediated cleavage [ 8].
As a statement it was notable for being the most relaxed Perry has sounded about his most famous role for some time.
Stone's next notable role, opposite Robert De Niro in Martin Scorsese's "Casino," was nominated for an Academy Award, and won her a Golden Globe.
Woolway had a notable role at Yammer helping it raise $142 million and then selling the company to Microsoft for $1.2 billion.
Here, the report said, Switzerland had "played a notable role".
Still, O2 has a notable role in the UK market.
Munn is a fan favorite for notable roles in pictures including "X-Men: Apocalypse," "Ride Along 2" and "Mortdecai".
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