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Other notable pathways are 'Regulation of actin cytoskeleton' and 'Circadian rhythm'.
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It is notable that few pathways are identified at an FDR of 0.1 in the combined treatment group compared to vehicle control, given how many significant differences we observed in the gene-to-gene analysis.
Notable was that several pathways were targeted by more than 5 DE miRNAs.
Notable among the enriched pathways were those for carbohydrate catabolism, including starch and sucrose metabolism (ko00500), and amino sugar and nucleotide sugar metabolism (ko00520).
Notable among the decreased pathways were those for fat and protein metabolism, including fatty acid biosynthesis (ko00061), phenylalanine metabolism (ko00360), and tryptophan metabolism (ko00380).
The other most notable pathway that was obviated by our analysis relates to the significant impact that A20 had on cell cycle in hepatocytes.
Both these pathways were found to be notable in glioblastoma, glioma, lung adenocarcinoma, and lung squamous cancer.
Although discussing each of the modulated pathways is beyond the scope of this study, some notable generalizations can be addressed.
The chemokine signaling pathway and the cytokine-cytokine receptor interaction pathway are both notable in low grade glioma.
The notable pathways in ovarian cancer are all notable pathways in the pan-cancer analysis, and were previously discussed.
There are 7 notable pathways in the case of colon adenocarcinoma, and all of them were found to be significant in the pan-cancer analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com