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One of the most notable mechanisms of GR activation in chronic inflammatory bile duct disorders such as PBC may include stimulatory effects on AE2 expression, thus increasing cholangiocyte bicarbonate secretion and stimulation/restoration of the biliary bicarbonate umbrella (see Fig. 1).
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With this in mind, it is notable that mechanisms underlying tissue specificity of mitochondrial disorders have yet to be elucidated, although retrograde signaling was suggested to play a role (Raimundo et al. 2012).
It is notable that redundant mechanisms used by the trigeminal system to detect the naturally occurring chemicals tested are also sufficient to detect at least one potentially dangerous compound that has no natural source, cyclohexanone.
It seems notable that no mechanism beyond a vague reference to stretch and integrin signaling was offered by the Cook paper to explain ligand-independent AT1R activation in the heart.
Our classification of virulence factors as pathogen-associated or "common" allowed for some notable observations regarding common mechanisms of virulence.
With a few notable exceptions, the specific mechanisms through which environmental triggers operate remain largely uncharacterized to date.
The third notable difference in resistance mechanisms against Pst and Bgt infection in wheat was that the similar serine/threonine-protein kinase FLS2 genes were implicated in protecting wheat seedlings from infection by the two fungi.
However, there are notable parallels between the three mechanisms of epistasis and the local heterozygosity mechanisms.
This notable feature and the mechanism proposed in this study extend the knowledge on nanoscale chemical transformations.
One notable prediction of this mechanism is that clustering of multi-copy transcription sites would be a particularly efficient way to increase the local density of sense and antisense RNA.
But Schaible clarifies that there is a notable difference between the two mechanisms at play here.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com