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The expression of several genes with notable fold change values was confirmed by QRT-PCR.
Fourteen genes with notable fold change values were selected for validation based on the results of functional annotation.
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Only serial exposure of C8395 to azithromycin resulted in notable (≥4 fold) increases in aminoglycoside MICs (Table 1).
Although substrate protection from MTSES was variable among these positions, the protection afforded T314C was particularly notable (2.1-fold) [ 16].
Survivors of neuroblastoma in our study had a notable 11-fold increased relative hazard of myocardial infarction.
In their identification of LETM1 as a mitochondrial Ca2+/H+ antiporter, Jiang and colleagues found that siRNA-mediated silencing of Letm1 in Drosophila S2 cells resulted in a modest although notable (~1.3-fold) increase in ΔΨmito (Jiang et al., 2009).
We investigated whether this might reflect Flt3-ITD-induced perturbation at the earliest B cell commitment stages, and in support of this found a notable 11-fold expansion of Lin−CD19−CD24−AA4.1+CD43midB220+ pre-pro-B cells in Flt3 ITD/ITD mice, whereas pro-B cells, the next stage in B cell development, were severely reduced.
It is notable that the fold increase in expression of both GIMAP8 and SPINK1 is markedly higher when quantitated by Northern blot rather than when quantitated by microarray.
Despite significant ontological clusters, it is notable that the fold changes in genes in the clusters mentioned above were themselves very moderate by array, possibly explaining why only some expression changes were able to be validated by qPCR.
We found hypoxia (5%and1%1% O2) induced a slight but notable increase (∼1.5-fold) in p38 phosphorylation (Supplementary information, Figure S4G and S4H).
Following depletion of RPL11, significant increase in transcripts of all three targets was noted with the most notable increase (16.2-fold) seen for p21.
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