"notable challenge" is correct and usable in written English.
You can use it to describe a task that is considered difficult to accomplish. For example: "The marathon runner faced a notable challenge, having to run for twenty-six miles without stopping."
"Genome editing in human T-cells has been a notable challenge for the field," Dr Marson said.
A notable challenge associated with the catalysis is its stability or photocorrosion, which lacks established protocols.
At present, dealing with the piracy and tampering of images has become a notable challenge, due to the presence of smart mobile gadgets.
Since most fungal infections occur in immunocompromised patients, the generation of tools relying on host immunity for effectiveness is a notable challenge.
Treatment of selenium containing waste streams poses a notable challenge to environmental engineers, and to date no ultimate solution has been found for e.g. the selenium contamination in agricultural areas of the western USA.
Structural characterization of the evolving minute nano-scale concentration fluctuations during SD in the Fe Cr system is, however, a notable challenge, and has mainly been considered accessible via atom probe tomography (APT) and small-angle neutron scattering.
"It is intriguing that we have some notable challenges to the political establishment that are not coming from a traditional American religious place but from a surprisingly secular tradition," said David Voas, head of the social science department at University College London.
And though the chefs face notable challenges — thanks, in part, to geography and limited infrastructure — the ventures offer a way for them to infuse their brands with a tropical appeal.
The simulation of plasmon resonances presents notable challenges.
Some notable challenges of the PEMFC technology are discussed in this paper.
One of the notable challenges faced by current network intrusion systems in cloud computing is the handling of massive internet traffic during DDoS attacks.
