We show that 2R-WGD preferentially retained genes are associated with higher organismal complexity (for example, locomotion, nervous system, morphogenesis), while genes associated with basic cellular functions (for example, translation, replication, splicing, recombination; with the notable exception of cell cycle) tended to be excluded.
We show that 2R-WGD preferentially retained genes associated with higher organismal complexity (for example, locomotion, nervous system, morphogenesis), while genes associated with basic cellular functions (for example, translation, replication, splicing and recombination, with the notable exception of cell cycle) tended to be excluded.
In contrast, 5F 203-insensitive cells (AHR100) failed to demonstrate any notable effect on the cell cycle, in particular S, G2/M and sub-G1 phases.
Among the proteins that change significantly, there was notable downregulation of three essential cell cycle regulators (CtrA, DnaA and GcrA), and two proteins (PopZ and ParA) that mediate chromosome segregation [13], [19], [20].
Although many studies indicate that Cdk5 is a regulator for cytoskeletal organization and signal transduction, rather than cell cycle, some notable facts remain.
In other words, it is involved in most of hallmarks of cancer [ 38, 88], with a notable exception of loss of cell cycle control.
In the histograms, the first notable chrysotile-induced alteration in the cell cycle was an increase in hypodiploid/apoptotic cell formation.
A notable difference is the absence of cell cycle categories among the top 30 biological processes assigned to cluster C in the analysis using DAVID.
Interestingly, there is a difference in the transcriptome upon NF-YA or NF-YB inactivations; in the latter, the most notable term in GO analysis is cell cycle, among which G2/M genes stand out, in line with the notorious abundance of CCAAT boxes in G2/M promoters.
