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Y. lipolytica strains, can induce a notable accumulation of reserve lipid when grown on hydrocarbons and fatty substrates.
This was also true with human TRIM21 and TRIM22, where VLPs made in the presence of TRIM21 and TRIM22 showed notable accumulation of premature Gag proteins, particularly in VLPs (Fig. 7A).
When examining the wounds microscopically we noticed that in the Mmp13 Plau double-deficient wounds the epidermal layer was often multilayered with notable accumulation of keratinocytes protruding into the dermis below (Figure 3, D and J).
Picrosirius Red staining showed that TGF-β induced a notable accumulation of strongly birefringent red collagen fibers, indicating highly cross-linked collagen, in the dermal compartment.
Specifically, the analysis of the spectra from the control and metformin treatments indicated that metformin treatment induced a notable accumulation of the one-carbon metabolism inter-mediate 5-formimino-tetrahydrofolate (5-formimino-THF) in each of the three breast cancer cell lines (Fig. 1B, Supplementary Fig. 1).
As shown in Figure 4, a marked influx of cells composed of monocytes and neutrophils was observed in mice instilled with 100 μg wildfire PM10 2.5 within the peribronchial tissues of the airways, along with an increased cellularity of septal tissues in the lung parenchyma with notable accumulation of inflammatory cells in the centriacinar airspaces of the lungs.
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Caspase-8 is particularly enriched in the skin [20], with a notable accumulation in the differentiating layers of the epidermis (Figure 1A, B and Figure S1A and B).
When p18Ink4c plasmid was introduced to the surrounding cells, the distribution of CldU single-labelled nuclei of p18Ink4c plasmid-negative cells showed a notable accumulation close to the apical surface, indicating that apical-to-basal nuclear migration is perturbed.
Notable was the accumulation of the non-proteinogenic amino acid GABA (1.8 FC), hydrophobic branched chain amino acids glutamine (12 FC), valine (1.6 FC), leucine (2.8 FC), and serine (2.2 FC) and shikimate derived phenylalanine (1.6 FC) and tyrosine (3.0 FC).
Most notable is the 0.03 accumulation of deficits and the age independent limit to frailty of 0.67.
Especially notable here is the accumulation of ammonia in the blood.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com