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Many children are familiar with the Tesla coil - used at science demonstrations and lectures to demonstrate what happens when you discharge a high voltage (but low current: it's current that kills, not voltage) over a small space.
Both types of cells have voltage-sensitive as well as not voltage sensitive potassium channels.
The circuit differs from the classical approximating converter in that it is not voltage but frequency approximation.
These channels are constitutively open and not voltage gated and, remarkably, transport cations most effectively at an acidic pH.
The current recorded from cells exposed to IpaB showed a simple, almost linear, I/V relation, suggesting that the effector forms a channel that is not voltage gated.
The pores formed by NodO in planar lipid bilayers are relatively large (>2 nm) and remain stably open for rather long, but are not voltage gated.
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From −90 mV to −10 mV the current was not voltage-dependent (Figs. 5C).
The effect of ANP was not voltage-dependent, since ANP induced propotional reduction of peak ICaL at all potentials tested (Fig. 3B). Figure S1 shows concentration-response relation between ANP and the ICaL.
The major difference between these two methods is that in ERG the rate of photoresponse recovery may be modified by the voltage-dependent channels in the rod inner segment, while the suction pipette responses are not voltage-dependent in the physiological voltage range.
10.7554/eLife.03819.017 Figure 4. Distribution of TRPV1-GFP mobility in HEK293T/17 cell (not voltage-clamped; see 'Materials and methods').
They are not voltage-gated (i.e. do not require a change in membrane potential to open) but they are often voltage-sensitive like other TRP channels [1,2].
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CEO of Professional Science Editing for Scientists @ prosciediting.com