That the regulation of Nkx3.1 levels is complex is evidenced by the fact that while Nkx3.1 levels are androgen regulated in adult prostate epithelial cells, these levels are not under androgen regulation during prostate development[59].
The experiment also showed that there are many mRNAs which have seeds homologies but are not under the regulation of the transfected miRNAs (false MREs).
Also, Nkx3.1 is expressed in a number of other cell lineages during development, including somites, and these lineages are not under androgen regulation.
Variability of expression of a gene would therefore mostly depend on its ability to be re-localized to a different region of the nucleus upon induction, and this capability would be independent from the overall level at which it can be expressed when it is not under epigenetic regulation.
Genes active in metabolic routes which are not under genetic regulation and thus do not produce eQTLs, are not represented.
In contrast, the concentration of trigger factor, a cotranslational chaperone not under σ32 regulation, was largely unchanged over this time period.
K. olearia appears to only contain cobT'-cobU-hyp-cobS and has no riboswitch, suggesting it is not under B12 regulation.
These results suggest that at least most of SOS response genes are not under the regulation of LexA in Synechocystis sp. PCC6803.
However, the orthologs of mutS is not under the regulation of LexA in E. coli [ 2, 33] or within the putative LexA regulon of any other cyanobacteria (Table S1-26 in Additional file 4).
We did not detect statistically significant changes in gene expression or protein levels of PRDM16, which may be a matter of the time point from which the tissue was assayed or further support that thermogenesis in epididymal fat is not under PRDM16 regulation (36).
