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The dominant influence of codon bias over other factors also explains why the use of different cost types in the multivariate regression model does not substantially effect the predictive power.
Therefore, the assumption of equivalent dissociation properties for E4P, R5P, RU5P, S7P and X5P does not substantially effect our calculations.
Such variations do not substantially effect the subsequent discussion and mechanisms, although they will change the absolute values of CO2 concentration in the carboxysome.
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We adjusted the model for a linear effect of age, and in our sample of exclusively male participants, the inclusion of BMI as a predictive variable did not substantially change effect size estimates or the statistical significance.
Studies may suffer from residual confounding from factors such as lifestyle (e.g., diet, physical activity) and/or other occupational exposures; however, some studies have shown that adjustment for risk factors such as smoking does not substantially change effect estimates [ 100].
Knowledge of result did not substantially modify these effects.
For E. adustus and A. semiberbis the addition of the third species does not substantially modified the effect obtained when competing in pairs.
To increase precision of the estimate of interest, if removal of a covariate did not substantially alter the effect estimate of the primary exposure, that covariate was not included in the models presented here.
To summarize of our secondary tests for validity, we concluded that reverse causality, recent food and supplement consumption, and total lipid levels did not substantially bias our effect estimates for the 5 validated factors.
Excluding participants with comorbidities potentially leading to RLS did not substantially change the effect estimates.
Further adjustment for physical activity in pregnancy did not substantially change the effect estimates.
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