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The molecular reasons why clear cell ovarian cancer cells, but not serous cells, are sensitive to sorafenib at present remains unclear.
These observations agree with our previous finding of a methylator phenotype occurring in endometrioid endometrial tumors but not serous endometrial tumors [ 25], as well as results reported by TCGA [ 26].
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The expression of Twist was a significant prognostic factor in non-serous type although not in serous type (OS; P<0.0001 and P=0.186, respectively).
The highest quintile of dairy fat intake was associated with overall, but not with serous, ovarian cancer risk when compared to the lowest intake.
Oestrogen plus progestins use was not associated with serous or endometrioid tumours in the Nurse's Health Study, but it was associated with increased serous and endometrioid tumours in the Danish Sex Hormone Register Study (Danforth et al, 2007; Morch et al, 2012).
Surprisingly enough, mutations in Fbxw7 are not common in serous ovarian cancers.
Any study that did not address the "serous" histologic types of endometrial cancer was excluded.
This positive association was not seen for serous epithelial ovarian cancer (RRQ5 vs Q1=0.76, 95% CI=0.42 1.39).
Lactose or dairy fat intakes were not associated with serous ovarian cancer risk.
In this case, the tumor replaced all gastric wall layers and invaded perigastric fat tissue but did not infiltrate the serous membrane.
ARID1A is a mutated gene in a significant portion of CCCs and ECs, but it is not detected in serous ovarian tumors [ 18].
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