Eugenol, a frequent sensitizer, does not sensitize CYP1A1 knockout mice, whereas the wild-type mice are sensitized to eugenol.
These findings have encouraged extensive research into identifying potent TRAIL-sensitizing agents that do not sensitize non-transformed cells.
Although CerS2 heterozygosity in mice did not sensitize mice to light, CerS2 null mice were significantly more sensitive to light than CerS2 +/+ mice (Fig. 7).
Combined treatment with ouabain did not sensitize HeLa S3 cells to etoposide or actinomycin D (Fig. 4H and I).
Ho, Y. S. et al. Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia.
The radC strain was normal for host cell reactivation of gamma- and UV-irradiated bacteriophage lambda; the radC mutation did not sensitize a recA strain, but did sensitize radA and polA strains to X and UV radiation, and a uvrA strain to UV radiation.
However, as seen with other RCC cell lines36, knockdown of MCL-1 with siRNA did not sensitize ACHN cells to TRAIL (data not shown) suggesting that loss of MCL-1 may play only a minor role, if any, in sensitization of ACHN cells to TRAIL by rocaglates.
Because the no-pain condition probably does not sensitize skin receptors, after the hand was removed from the water subjects rested about 10 min between no-pain and pain sessions (Fig. 2).
Likewise, knock-down of IMPDH2 gene expression did not sensitize Saos-2 wild-type cells to cisplatin or methotrexate.
However, loss of UPR signaling did not sensitize these cells to the alkylating agent methyl methane sulfonate (MMS) or to ultraviolet irradiation (Fig. 6).
In addition, we conclude that the increased sensitivity to nocodazole observed after CAP350 depletion is specific because defective initiation of centriole biogenesis did not sensitize the duplication process to this microtubule-depolymerizing drug.
