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The "non-responder" group (but not "responder") had significantly reduced values for lymphocyte, null-cell and E-rosette-cell counts compared with controls.
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"They're not responders," Dr. Flaherty gently corrected him: under the accepted definition, tumors had to shrink to qualify patients as responders.
Three responders from group 1 in whom the dose of corticosteroids had been reduced were not responders at M2 anymore.
Patients with a TRG 1 or 2 score were considered as responders, whereas the remaining patients (TRG 3, 4, or 5) were classified as not responders [ 9].
In one study, Correll et al found that every patient whose symptoms had not improved by 20% after one week of treatment were not responders after four weeks.
Based on their clinical response at week 12, subjects were categorised into ACR20 non-responders (no response at week 12), ACR50 non-responders (ACR20 responders, but not ACR50 responders) and ACR70 non-responders (ACR50 responders, but not ACR70 responders).
Eligible study subjects can either respond (responders) or not respond to the study invitation (non-responders).
Ji-square and U-Mann Whitney test were used to compare results between treatment responders and not-responders.
Interestingly, in not-responder patients we observed a rapid increased in VEGF levels kept until disease progression while in responder-ones VEGF levels resulted unchanged.
In not-responder ones treatment is uneffective, newly formed endothelial tumor cells spread and we observe an increased VEGF levels contributing to a rapid disease progression.
Not-responders patients showed a low baseline VEGF levels respect to responder ones in contrast with Briasuolis et al. [ 8].
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