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However, cell lines are clonally homogenous and are not recapitulating the complex tumor microenvironment in vivo.
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Commercially available ECM products, such as collagen and GelTrex, did not recapitulate drug binding behavior.
Contemporary systems for in vitro culture of ovarian follicles do not recapitulate the mechanical heterogeneity in mammalian ovary.
Another issue is that many studies injected GBM in the dorsal flanks of mice, which do not recapitulate GBM in human.
While mice deficient in XPA have been created, they did not recapitulate the neurological degeneration phenotypes observed in humans (Nakane et al., 1995).
We may reasonably conclude, therefore, that 1) 3D printing will not recapitulate the history of 2D printing, 2) as soon as you make an argument along those lines you lose all credibility and look like an idiot.
In some instances, murine models of allergic asthma have not recapitulated the human findings, and have led to some costly failures in drug development.
Current models do not recapitulate the basaloid phenotype of TNBC, thus limiting the understanding of its biology and designing new treatments.
Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment.
However, there is still variable predictability of continued root development and evidence that the tissues formed do not recapitulate the native pulp-dentin complex.
However, these observations are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal breathing and DIs) in isolated intact airways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com