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One methodological limitation of this cost analysis is that it was based on a single study centre and was not randomised.
Patients were not randomised and the cohorts are heterogeneous, with significant imbalances at baseline (e.g. severity scores, prevalence of sepsis) and many potential confounders on outcome.
Out of the eleven studies, three satisfied the inclusion criteria and were included (n = 249); two studies were follow-ups of RCTs and one was not randomised.
We excluded animal studies, reviews, letters, abstract-only trials, open-label trials, and trials that were not randomised.
Not randomised controlled trial.
Two patients were not randomised.
This study is not randomised.
Children who were ill were not randomised.
Importantly this is not randomised data.
40 Patient allocation to surgery was not randomised.
As to limitations, the sample was not randomised.
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