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One should remember, however, that many of these data were not originally defined for the purpose of evaluating the staging system, but with some other scientific questions in mind.
What were not originally defined as part of the core complex were mitoribosomal proteins, although crude mass spectrometry data on immunoprecipitated mitoribosomes did report the association of various nucleoid-associated proteins [116].
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Although epigenetic mechanisms have been shown to be passed on across generations (Jablonka and Raz 2009), Lamarckian inheritance as originally defined does not occur (see entry on inheritance systems).
However, there is not one single published report of chromosomal rearrangement mediated via rhs elements and hence it is clear that these loci are not 'rearrangement hot spots' as originally defined by Hill and co-workers [ 26].
The SPS+A configuration was originally defined as not only having the inverted pairs of Su(H) sites separated by 17 bp, but also having a T in the "Y" position of the upstream Su(H) site and a C in this position in the downstream site [ 13, 24].
These new relationships suggest that the supergroup 'Chromalveolata', as originally defined [16], does not correctly explain the evolutionary history of organisms bearing plastids derived from a red algae.
The six dimensions of the PEmb-QoL were originally defined clinically and not statistically, assuming that these six dimensions would provide unique information to the treating physician [ 7].
MPF, as originally defined, is thus not synonymous with cyclin B-Cdk1, but is instead a system consisting of both cyclin B-Cdk1 that directs mitotic entry and Gwl that suppresses the anti-cyclin B-Cdk1 phosphatase.
Quantification of HIV-1 viraemia revealed that the majority of persons originally defined as LTNPs did not control viral replication, and disease progression in these patients occurred eventually, although less rapid than in typical HIV-1+ individuals [8].
The reason for this is that they were originally defined for reimbursement and were not meant to define the SHI benefit basket in full detail.
Bridgman thus emphasized that our concepts did not automatically extend beyond the domains in which they were originally defined.
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