Although a closed-form optimal solution is available for the convex reformulation, such an approximation at high SNR regions does not always hold in practice.
In the case of multiple alignment of contact maps, although the neighbor-joining method is not optimal, it has been shown in practice to perform nearly as well as an optimal, exhaustive search for multiple sequence alignment (Gascuel and Steel, 2006).
In contrast, traditional game assumptions for perfectly optimal decisions are often not feasible in practice.
The voltage sent to the disturbance speaker provides an optimal reference signal which is not realistic in practice.
Although this method yields globally optimal switching time sequences, it is not feasible in practice due to its computational complexity.
Equation (12) is a non-convex combinatorial optimization problem, thus, computing its globally optimal solution may not be feasible in practice.
Although lifestyle interventions, such as advice on diet, physical exercise, smoking and alcohol, have moderate, but potentially relevant effects in these patients, adherence to lifestyle advice in general practice is not optimal.
However, it is not easy to determine the optimal point on the Pareto optimal set in practice depending on the variety of culture conditions.
Furthermore, although optimal detection is not generally feasible in practice, it remains important as a benchmark reference, and will therefore be considered in this article.
"It might not come in practice.
